H1N1 Infection-Related Hemophagocytic Lymphohistiocytosis in a Child
نویسندگان
چکیده
Hemophagocytic lymphohistiocytosis (HLH) is a clinical condition characterized by macrophage and activated histiocyte proliferation, leading to uncontrolled phagocytosis of hematopoietic precursor cells. The clinical presentation is characterized by fever, pancytopenia, hepatosplenomegaly, and hemophagocytosis in the reticuloendothelial system. In addition to the primary form of the disorder, secondary HLH has been associated with a variety of infections, malignancy, and autoimmune disease [1]. Virus-associated HLH is a well-recognized clinical condition. Most cases are related to Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus 6, and human herpes virus 8 infections [2]. H1N1 influenza-associated HLH has been reported in children extremely rarely [3,4]. We present here a successfully treated case of severe H1N1 influenza-related HLH.
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